Endocrine Abstracts

Despite the importance of the Ret receptor, it is clear that other signal transduction pathways, tyrosine kinase receptors, and tumours suppressor genes are involved in MTC tumorigenesis and progression. Differences in the clinical behaviour of patients harbouring the same Ret mutations may be related to these other genes. Alterations of genes involved in the G1 phase of the cell cycle, including the cyclins, CDKs and CDK inhibitors, are common events in neoplastic development...

Introduction: Graves’ ophthalmopathy (GO) varies from minor changes to visible face disfigurement which may compromise the visual capacity and the aesthetics of the patient. These deformities affect the quality of life in both functional and emotional senses. There are some questionnaires designed to evaluate the patient’s health, quality of life and relationship with a specific disease. The use of these questionnaires is recommended to improve the quality of care an...